Healing & Recovery
VIP
Vasoactive intestinal peptide — endogenous 28-amino-acid signalling molecule with broad immune and vascular effects.
- Half-life
- ~1–2 minutes in plasma
- Route
- Intranasal, inhaled, intravenous (trial)
Overview
VIP is an endogenous peptide of the secretin family, active throughout the gut, brain, lungs and immune system.
Mechanism of action
Agonism of VPAC1 and VPAC2 G-protein coupled receptors, producing vasodilation, bronchodilation, anti-inflammatory cytokine shifts and pancreatic exocrine stimulation.
Evidence base
Investigated in sarcoidosis, chronic inflammatory response syndrome (CIRS), pulmonary hypertension and post-COVID inflammation. Aviptadil received FDA emergency-use consideration during COVID-19.
Typical dosing
Intranasal compounded protocols in CIRS practice cite 50 mcg 4× daily. Inhaled and IV forms exist under research protocols. Open the dose calculator →
Safety & contraindications
Hypotension and flushing possible with parenteral use. Intranasal use should follow MSH and other pituitary evaluations per the Shoemaker protocol.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.