Healing & Recovery
TB-500
Synthetic fragment of thymosin beta-4 promoting cell migration and tissue remodelling.
- Half-life
- Full-length TB4: ~2 hours; TB-500 fragment presumed similar.
- Route
- Subcutaneous or intramuscular
- Storage
- Refrigerate reconstituted vial; use within 60 days.
Overview
TB-500 is a synthetic version of the active region of thymosin beta-4, a naturally occurring 43-amino-acid peptide involved in actin regulation and cellular repair.
Mechanism of action
Binds G-actin to regulate cytoskeletal assembly, promotes endothelial cell migration and angiogenesis, and downregulates inflammatory mediators after injury.
Evidence base
Preclinical models of cardiac, corneal, skin and musculoskeletal injury show accelerated repair. Early human cardiac trials of full-length thymosin beta-4 (RegeneRx) established safety at intravenous doses.
Typical dosing
Loading protocols commonly cite 2–2.5 mg twice weekly for 4–6 weeks, followed by maintenance at 2 mg every 1–2 weeks. Open the dose calculator →
Safety & contraindications
Generally well tolerated in trials of thymosin beta-4. Theoretical concern regarding angiogenesis in occult malignancy — screen before use.
Common stacks
Frequently combined with BPC-157 for soft-tissue injury.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.