Healing & Recovery
Thymosin Beta-4
Naturally occurring 43-amino-acid actin-regulating peptide; parent molecule of TB-500.
- Half-life
- ~2 hours
- Route
- Subcutaneous, intramuscular, ophthalmic (trial formulations)
Overview
Thymosin beta-4 (Tβ4) is the most abundant member of the beta-thymosin family, expressed in nearly every human cell and involved in cytoskeletal regulation.
Mechanism of action
Sequesters G-actin monomers, promotes endothelial cell migration and angiogenesis, downregulates NF-κB inflammatory signalling and modulates stem-cell recruitment to injured tissue.
Evidence base
Full-length recombinant Tβ4 (RGN-259, RGN-352) completed phase 2/3 in dry-eye disease and neurotrophic keratopathy with encouraging results. Cardiac and dermal wound trials showed safety.
Typical dosing
Research protocols vary widely; longevity practice typically uses 2 mg subcutaneously 1–2 times weekly. Open the dose calculator →
Safety & contraindications
Generally well tolerated in trials. Same theoretical malignancy concern as TB-500 given angiogenic activity.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.