VAHEBIO — Science · Longevity · Optimised
The Compendium

Weight Management

Adipotide

Peptidomimetic that induces apoptosis in white-adipose tissue vasculature.

Route
Subcutaneous (research)

Overview

Adipotide (FTPP) is a chimeric peptide developed at MD Anderson that targets prohibitin on white-adipose endothelial cells and delivers a pro-apoptotic KLAKLAK sequence.

Mechanism of action

Selectively binds vasculature that supports white adipose tissue, triggering endothelial apoptosis and involution of the fat depot. Preserves brown adipose tissue.

Evidence base

Primate studies showed ~11% body-weight reduction and improved insulin sensitivity over 4 weeks. Human trials halted early due to renal toxicity concerns.

Typical dosing

Only administered under research conditions historically; no established human dosing. Open the dose calculator →

Safety & contraindications

Dose-dependent nephrotoxicity is the primary concern. Not recommended for use outside monitored research settings.

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Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.