Mitochondrial
SS-31 (Elamipretide)
Cardiolipin-targeted tetrapeptide (elamipretide) that stabilises the inner mitochondrial membrane.
- Half-life
- ~2 hours
- Route
- Subcutaneous
Overview
SS-31, developed clinically as elamipretide (Bendavia), is a synthetic tetrapeptide that concentrates in the inner mitochondrial membrane by binding cardiolipin.
Mechanism of action
Stabilises cristae architecture, restores efficient electron transport, reduces reactive oxygen species and improves ATP production without acting as a free-radical scavenger itself.
Evidence base
Trials in primary mitochondrial myopathy, Barth syndrome and dry AMD have shown mixed but encouraging signals. FDA has considered accelerated approval pathways for rare mitochondrial indications.
Typical dosing
Trial dosing typically 40 mg subcutaneously daily. Open the dose calculator →
Safety & contraindications
Injection-site reactions dominant. Generally well tolerated across trials to date.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.