Cognitive
Semax
ACTH(4–10) analogue used in Russian neurology for stroke recovery and cognitive support.
- Half-life
- Rapid plasma clearance; CNS effects persist ~20–24 hours.
- Route
- Intranasal
Overview
Semax is a heptapeptide derived from adrenocorticotropic hormone (ACTH 4–10), developed in the 1980s at the Russian Academy of Sciences and included on Russia's list of vital medicines.
Mechanism of action
Rapidly upregulates BDNF and NGF expression, modulates the melanocortin system without triggering cortisol release, and enhances dopaminergic and serotonergic tone.
Evidence base
Russian trials in ischaemic stroke show improved neurological recovery when administered within the first hours. ADHD, optic-nerve neuropathy and cognitive-decline studies exist but predominantly single-centre.
Typical dosing
Intranasal 0.1% (research/nootropic) or 1% (acute stroke) solution: 2–4 sprays daily. Cycles usually 10–14 days. Open the dose calculator →
Safety & contraindications
Generally well tolerated; occasional mild headache. Outside Russia used off-label with no regulatory approval.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.