Cosmetic
GHK-Cu
Copper-binding tripeptide central to skin remodelling and hair follicle biology.
- Route
- Topical, subcutaneous, intradermal
Overview
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring plasma tripeptide first isolated by Loren Pickart in 1973. Levels decline sharply with age.
Mechanism of action
Delivers copper to enzymes involved in collagen and elastin synthesis, modulates ~30% of human genes toward a youthful expression pattern in fibroblast assays, and stimulates anagen-phase hair follicles.
Evidence base
Multiple RCTs in cosmetic dermatology confirm anti-wrinkle, firmness and pigmentation-evening effects. Hair-growth trials show modest but reproducible density improvements.
Typical dosing
Topical 0.05–2% serum daily. Subcutaneous research protocols cite 1–2 mg daily in short cycles; scalp mesotherapy uses low-dose intradermal injection. Open the dose calculator →
Safety & contraindications
Topical use is very well tolerated. Injectable use may cause transient blue discoloration at the injection site from the copper complex.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.