Cosmetic
Argireline
SNAP-25-mimicking hexapeptide used topically as a needle-free alternative to botulinum toxin.
- Route
- Topical
Overview
Argireline (acetyl hexapeptide-8) is a synthetic peptide developed by Lipotec that mimics the N-terminus of SNAP-25, one of the SNARE proteins targeted by botulinum toxin.
Mechanism of action
Competes with SNAP-25 in the SNARE complex, modestly reducing catecholamine-driven muscle contraction in the superficial dermis — a fraction of the potency of botulinum toxin.
Evidence base
Small dermatology studies report ~10–30% reduction in wrinkle depth after 4–8 weeks of daily topical use.
Typical dosing
Topical 5–10% serum applied to expression lines once or twice daily. Open the dose calculator →
Safety & contraindications
Topical use very well tolerated. Systemic absorption is negligible.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.