Metabolic
Xenin-25
Gut-derived 25-amino-acid peptide that amplifies GIP-mediated insulin release and reduces appetite.
- Half-life
- ~5 minutes
- Route
- Intravenous (research)
Overview
Xenin-25 is co-secreted with GIP from duodenal K-cells after nutrient ingestion. Human levels are blunted in type 2 diabetes.
Mechanism of action
Potentiates GIP-stimulated insulin secretion via cholinergic pathways, slows gastric emptying and centrally reduces food intake.
Evidence base
Human infusion studies restore GIP responsiveness in T2DM and reduce postprandial glucose. No approved formulation.
Typical dosing
Research infusion studies only; no established outpatient dosing. Open the dose calculator →
Safety & contraindications
Nausea at higher infusion rates is the most common effect. Limited chronic-exposure data.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.