Sexual Health
Kisspeptin-10
N-terminal fragment of kisspeptin driving upstream GnRH release and reproductive axis activation.
- Half-life
- ~28 minutes
- Route
- Subcutaneous, intravenous
Overview
Kisspeptin-10 is the shortest bioactive fragment of the KISS1 gene product. It sits at the top of the hypothalamic-pituitary-gonadal axis.
Mechanism of action
Binds KISS1R on GnRH neurons, triggering GnRH pulses that drive LH and FSH release and downstream gonadal steroidogenesis.
Evidence base
Human trials confirm robust LH/testosterone response in men and follicular development in women. Investigated for hypothalamic amenorrhoea, hypogonadotropic hypogonadism and IVF trigger.
Typical dosing
Research infusions of 4–128 nmol/kg produce dose-dependent LH surges. Subcutaneous longevity protocols cite 100–500 mcg daily, with far less human safety data. Open the dose calculator →
Safety & contraindications
Well tolerated in trials. Should not be used in hormone-sensitive malignancy or without an understanding of endogenous HPG status.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.