Anti-Aging
Epithalon
Russian-origin tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and pineal function.
- Half-life
- Short (minutes); effects attributed to gene-expression changes rather than plasma level.
- Route
- Subcutaneous
Overview
Epithalon (epitalon) is a synthetic tetrapeptide developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology.
Mechanism of action
Hypothesised to upregulate telomerase expression, extending telomere length in somatic cells; also proposed to normalise pineal melatonin secretion and cortisol rhythm.
Evidence base
Russian long-term cohort studies report reduced all-cause mortality in elderly participants. Western replication is limited; most claims rest on a single research group.
Typical dosing
Common protocol: 10 mg subcutaneously daily for 10–20 consecutive days, repeated 1–2 times yearly. Open the dose calculator →
Safety & contraindications
Reported as well tolerated in the Russian literature. Independent long-term safety data are sparse.
Related peptides
Educational reference only. Nothing on this page is medical advice, a prescription, or an offer to sell. Discuss any peptide therapy with a qualified clinician who can evaluate your history and monitoring needs.